Clinical indications - MedVision
 
 
 

Download the clinical indications for PET/CT

Clinical indications for PET/CT .pdf

Tumors of Lymphatic System

Hodgkin’s lymphoma

  • PET/CT is useful for tumor staging.
  • PET/CT is useful for determining the effects of chemotherapy.
  • PET/CT is useful for diagnosing potential tumor recurrence.
  • Non-Hodgkin’s lymphoma

  • PET/CT is potentially useful in tumor staging (essential for agressive lymphoma types: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, AIDS-related B-cell lymphoma, peripheral T-cell lymphoma).
  • PET/CT is possibly useful for determining the effectiveness of therapy (it’s the method of choice, if lymphoma cancer cells accumulated FDG prior to therapy).
  • PET/CT is potentially useful for cancer relapse diagnosis (useful, if lymphoma cancer cells accumulated FDG prior to therapy).
  •  

    Melanoma

  • PET/CT is useful for stage I and stage II patients with high likelihood of metastases.
  • PET/CT is potentially useful for stages III and IV.
  • PET/CT is useful for restaging or for relapse diagnosis.
  •  

    Prostate cancer

    Indications for 18F-choline PET/CT to patients with prostate cancer:

  • PET/CT is useful for primary staging
  • PET/CT is useful for radiotherapy planning and its evaluation of the effectiveness (systemic and salvage therapy)
  • PET/CT is useful with increase of the tumour marker PSA after removal/irradiation of the prostate (biochemical recurrence)
  • Indications for 68Ga-PSMA PET/CT to patients with prostate cancer:

  • Suspected recurrence of a tumour or metastasis with increase of the tumour marker PSA after removal/irradiation of the prostate (biochemical recurrence)
  • Exclusion of metastasis in lymph nodes, internal organs, and bones
  • Selection for systemic therapy Y-90 or Lu-177-PSMA
  • Suspected prostate cancer despite negative biopsy, such as the planning of a new, targeted biopsy
  •  

    Gynecological Tumors

    Breast Cancer

  • PET/CT is useful for diagnosing distal metastases in stages IIIa and IIIb with inconclusive findings using other diagnostic modalities.
  • PET/CT is indicated for inflammatory breast cancer.
  • PET/CT is indicated to determine the effectiveness of the therapy for local and/or metastatic spread of the disease.
  • PET/CT is indicated for restaging and diganosis of relapse.
  • Uterine and Cervical Cancer

  • PET/CT is indicated for staging uterine and cervical cancers stages Ib through IV; it is used mostly to diagnose diseases located outside of pelvical region and for diagnosing possible metastases in lymphnodes.
  • PET/CT is indicated for diagnosing cancer relapse.
  • PET/CT is indicated for restaging.
  • Ovarian cancer

  • PET/CT is potentially indicated for cancer staging.
  • PET/CT is indicated for diagnosing cancer relapse.
  •  

    Gastrointestinal Tumors

    Esophageal cancer:

  • PET/CT is indicated for cancer staging.
  • PET/CT is potentially indicated for cancer restaging.
  • PET/CT is potentially indicated for cancer relapse diagnoses.
  • Stomach cancer:

  • PET/CT is indicated for cancer staging.
  • Colorectal cancer:

  • PET/CT is potentially indicated for cancer staging (recommended, if CT provides inconclusive findings, or the administration of intravenous contrast agent is contrindicated).
  • PET/CT is indicated to evaluate the preoperative patients with potentially resectable metastatic disesase.
  • PET is superior to other diagnostic modalities in diagnosing extrahepatic metastasis, when liver metastasis are diagnosed by CT or USG.
  • PET/CT is indicated for cancer restaging. 18F-FDG PET examination before the liver resection changes therapy tactic in 1/3 of the cases.
  • Gastrointestinal Stromal Tumor (GIST)

  • PET/CT is indicated for tumor staging.
  • PET/CT is indicated for determining the effectiveness of treatment.
  • Gallbladder and Biliary Tumors

  • PET/CT is potentially useful for cancer staging (N and M)
  •  

    Lung Tumors

    Nasopharingeal Carcinoma

  • PET/CT is useful for tumor staging.
  • PET/CT is potentially useful for restaging or the diagnosis of cancer relapse.
  • Small Cell Lung Cancer

  • PET/CT is potentially useful for tumor staging.
  • PET/CT is possibly useful for expected cancer relapse diagnosis.
  • PET/CT is useful for planning radiotherapy treatment.
  • Non-small Cell Lung Cancer

  • PET/CT is useful for describing solitary pulmonary nodules.
  • PET/CT ir useful for staging of mediastinal lympnodes.
  • PET/CT is useful for extrathoracic staging and for ruling out distal metastases.
  • PET/CT is potentially useful after neoadjuvant chemotherapy.
  • PET/CT is possibly useful for diagnosing potential tumor recurrance.
  • PET/CT is potentially useful in radiation therapy treatment planning.
  •  

    Sarcomas (soft tissue and bone)

  • PET/CT is potentially useful to determine the outcome of the disease.
  • PET/CT is potentially useful for tumor staging.
  • PET/CT is possibly useful for restaging.
  • PET/CT is potentially useful for expected tumor relapse diagnosis.
  •  

    Endocrine Tumors

    Thyroid Cancer

  • PET/CT is useful for tumor restaging or for diagnosing reccuring tumors for differenciated thyroid cancer in special cases.
  • PET/CT is potentially useful for tumor restaging or expected cancer relapse diagnosis for medullary thyroid cancer.
  • Pancreatic Adenocarcinoma

  • PET/CT is possibly useful for characterization of pathological mass.
  • PET/CT is potentially useful for expected relapse diagnosis.
  •  

    Head and Neck Squamos Cell Tumors

  • PET/CT is useful for further evaluation of patients with a lymphadenopathy with unknown primary tumor.
  • PET/CT is useful for tumor staging (added value in determining lymphnode metastasis).
  • PET/CT is useful for evaluating patient condition at the end of the treatment.
  • PET/CT is useful for diagnosing cancer relapse.
  •  

    Germinal Tumors

  • PET/CT is potentially useful for determining the effectiveness of therapy (in case of seminoma PET/CT can differentiate residual tumor from necrosis/fibrosis).
  •  

    Kidney Tumors

  • PET/CT is possiblly useful for tumor staging.
  • PET/CT is possiblly useful for tumor restaging or diagnosing the relapse.
  •  

    Unknown Localization Tumor

  • PET/CT is the method of choice, if the patient has been diagnosed with metastases of squamous cell carcinoma in the head and/or neck lymphnodes.
  • PET/CT is potentially useful, if squamous cell metastases are found in the brain without known primary tumor.
  • PET/CT can be used if conventional diagnostic methods had failed to locate the tumor but the patient has an increase in FDG accumulating tumor markers.
  •  

    Primary CNS Tumors

  • PET/CT is possibly useful for managing the biopsy.
  • PET/CT is potentially useful in expected cancer relapse diagnosis.
  •